Establishing a new evaluation system to characterize radiation carcinogenesis by stem cell dynamics (Contract research); FY2021 Nuclear Energy Science & Technology and Human Resource Development Project

Collaborative Laboratories for Advanced Decommissioning Science; National Institutes for Quantum Science and Technology*

JAEA-Review 2022-051, 78 Pages, 2023/01

JAEA-Review-2022-051.pdf:7.12MB

The Collaborative Laboratories for Advanced Decommissioning Science (CLADS), Japan Atomic Energy Agency (JAEA), had been conducting the Nuclear Energy Science & Technology and Human Resource Development Project (hereafter referred to "the Project") in FY2021. The Project aims to contribute to solving problems in the nuclear energy field represented by the decommissioning of the Fukushima Daiichi Nuclear Power Station, Tokyo Electric Power Company Holdings, Inc. (TEPCO). For this purpose, intelligence was collected from all over the world, and basic research and human resource development were promoted by closely integrating/collaborating knowledge and experiences in various fields beyond the barrier of conventional organizations and research fields. The sponsor of the Project was moved from the Ministry of Education, Culture, Sports, Science and Technology to JAEA since the newly adopted proposals in FY2018. On this occasion, JAEA constructed a new research system where JAEA-academia collaboration is reinforced and medium-to-long term research/development and human resource development contributing to the decommissioning are stably and consecutively implemented. Among the adopted proposals in FY2019, this report summarizes the research results of the "Establishing a new evaluation system to characterize radiation carcinogenesis by stem cell dynamics" conducted from FY2019 to FY2021. Since the final year of this proposal was FY2021, the results for three fiscal years were summarized. In this study, we will use cell lineage tracing technology that can permanently label stem cells and their progenies to capture and mathematically model the long-term clonal proliferation of cells in mammary tissue after high to low dose radiation exposure to determine the origin of radiation carcinogenesis, the stem cells. The objective is to characterize radiation-induced breast cancer by its dynamics.

Establishing a new evaluation system to characterize radiation carcinogenesis by stem cell dynamics (Contract research); FY2019 Nuclear Energy Science & Technology and Human Resource Development Project

Collaborative Laboratories for Advanced Decommissioning Science; National Institutes for Quantum and Radiological Science and Technology*

JAEA-Review 2020-045, 52 Pages, 2021/01

JAEA-Review-2020-045.pdf:3.13MB

The Collaborative Laboratories for Advanced Decommissioning Science (CLADS), Japan Atomic Energy Agency (JAEA), had been conducting the Nuclear Energy Science & Technology and Human Resource Development Project (hereafter referred to "the Project") in FY2019. The Project aims to contribute to solving problems in the nuclear energy field represented by the decommissioning of the Fukushima Daiichi Nuclear Power Station, Tokyo Electric Power Company Holdings, Inc. (TEPCO). For this purpose, intelligence was collected from all over the world, and basic research and human resource development were promoted by closely integrating/collaborating knowledge and experiences in various fields beyond the barrier of conventional organizations and research fields. The sponsor of the Project was moved from the Ministry of Education, Culture, Sports, Science and Technology to JAEA since the newly adopted proposals in FY2018. On this occasion, JAEA constructed a new research system where JAEA-academia collaboration is reinforced and medium-to-long term research/development and human resource development contributing to the decommissioning are stably and consecutively implemented. Among the adopted proposals in FY2019, this report summarizes the research results of the "Establishing a new evaluation system to characterize radiation carcinogenesis by stem cell dynamics" conducted inFY2019. In this study, the long-term clonal expansion of mammary stem cells after high- to low-dose radiation exposure was investigated using stem-cell lineage tracing technology that can permanently label stem cells and their progenies. The purpose of this study is to characterize radiation-induced breast cancer based on the dynamics of radiation-exposed stem cells by capturing proliferation and analyzing it using a mathematical model. The goal of this study is to develop a new evaluation system that can characterize previously undiscovered "radiation signatures" by stem cell dynamics.

Preliminary analysis of sodium experimental apparatus PLANDTL-2 for development of evaluation method for thermal hydraulics in reactor vessel of sodium fast reactor under decay heat removal system operation condition

Ono, Ayako; Tanaka, Masaaki; Miyake, Yasuhiro*; Hamase, Erina; Ezure, Toshiki

Proceedings of 27th International Conference on Nuclear Engineering (ICONE-27) (Internet), 7 Pages, 2019/05

https://doi.org/10.1299/jsmeicone.2019.27.2318

Decay heat removal system (DHRS) by using the natural circulation without depending on the pump as the mechanical equipment is recognized as one of the most effective methodologies for the sodium-cooled fast reactor from the viewpoint of the safety enhancement. In this paper, the numerical simulation results of the preliminary analysis for the sodium experiment with the apparatus of PLANDTL-2, in which the core and the upper plenum with a dipped-type direct heat exchanger (DHX) were modeled, were discussed, in order to establish appropriate numerical models for the reactor core including the gap region among the subassemblies and the DHX.

On the mathematical model with morphological change of tumorigenesis in view

Ouchi, Noriyuki

Hoken Butsuri, 40(2), p.166 - 169, 2005/06

https://doi.org/10.5453/jhps.40.166

Development of the new mathematical model of the carcinogenesis in a low dose in mind is reported. The new model which describes from cell canceration to the tumorigenesis in consideration of the physical dynamics of a cell level was built. In a cell group level, it has both intra-cellular dynamics, such as mutation, cell division, and cell death, and physical dynamics such as, adhesion between cells, modification, and movement, and a model can investigate with time that tumor is formed.

Applicability of a model predicting iodine-129 profile in a silver nitrate silica-gel column for dissolver off-gas treatment of fuel reprocessing

Mineo, Hideaki; Goto, Minoru; Iizuka, Masaru*; Fujisaki, Susumu; Hagiya, Hiromichi*; Uchiyama, Gunzo

Separation Science and Technology, 38(9), p.1981 - 2001, 2003/05

https://doi.org/10.1081/SS-120020130

no abstracts in English

In-phantom two-dimensinal thermal neutron distribution for intraoperative boron neutron capture therapy of brain tumours

Yamamoto, Tetsuya*; Matsumura, Akira*; Yamamoto, Kazuyoshi; Kumada, Hiroaki; Shibata, Yasushi*; Nose, Tadao*

Physics in Medicine & Biology, 47(14), p.2387 - 2396, 2002/07

https://doi.org/10.1088/0031-9155/47/14/302

The aim of this study was to determine the in-phantom thermal distribution derived from neutron beams for intraoperative boron neutron capture therapy (IOBNCT). Gold activation wires arranged in a cylindrical water phantom with (void-in phantom) or without (standard phantom) a cylinder styrene form placed inside were irradiated by using the epithermal beam (ENB) and the mixed thermal-epithermal beam (TNB-1) at the JRR-4. The thermal neutron distribution derived from both the ENB and TNB-1 was significantly improved in the void-in-phantom, and a double high dose area was formed lateral to the void. The flattened distribution in the circumference of the void was observed with the combination of ENB and the void-in-phantom. The measurement data suggest that the ENB may provide a clinical advantage in the form of an enhanced and flattened dose delivery to the marginal tissue in which residual and/or microscopically infiltrating tumor.

A Simple model predicting iodine profile in a packed bed of silica-gel impregnated with silver nitrate

Mineo, Hideaki; Goto, Minoru; Iizuka, Masaru*; Fujisaki, Susumu; Uchiyama, Gunzo

Journal of Nuclear Science and Technology, 39(3), p.241 - 247, 2002/03

https://doi.org/10.3327/jnst.39.241

no abstracts in English

Development of a code to simulate dispersion of atomospheric released tritium gas in the environmental media and to evaluated doses: TRIDOSE

Murata, Mikio*; Noguchi, Hiroshi; Yokoyama, Sumi*

JAERI-Data/Code 2000-034, 214 Pages, 2000/11

JAERI-Data-Code-2000-034.pdf:7.43MB

no abstracts in English

Temperature analysis of solid methane particle and a container for thermal neutron moderator

Aso, Tomokazu; Ishikura, Shuichi*; Teshigawara, Makoto*; Hino, Ryutaro

JAERI-Tech 97-063, 59 Pages, 1997/12

JAERI-Tech-97-063.pdf:1.83MB

no abstracts in English

The use of color to quantify the effects of pH and temperature on the crystallization kinetics of goethite under highly alkaline conditions

Nagano, Tetsushi; *; ;

Clays and Clay Minerals, 42(2), p.226 - 234, 1994/00

https://doi.org/10.1346/CCMN.1994.0420213

no abstracts in English